Erythrophagocytosis by Neutrophils in Paroxysmal Cold Hemoglobinuria
نویسندگان
چکیده
منابع مشابه
Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria.
The clinical management of paroxysmal nocturnal hemoglobinuria (PNH), a rare but life-threatening hematologic disease, has fundamentally improved with the introduction of a therapeutic that prevents complement-mediated intravascular hemolysis. However, a considerable fraction of PNH patients show insufficient treatment response and remain transfusion dependent. Because the current treatment onl...
متن کاملThe Population of Paroxysmal Nocturnal Hemoglobinuria Neutrophils Deficient in Decay -
In patients with paroxysmal nocturnal hemoglobinuria (PNH) the RBCs, neutrophils (PMNsh monocytes, and platelets derived from the abnormal clone are deficient in the complement-regulatory protein decay-accelerating factor (DAF). RBC acetyicholinesterase (AChE) and leukocyte alkaline phosphatase (LAP) activities are also characteristically low. DAF, AChE, and LAP are known to be anchored within ...
متن کاملErythrophagocytosis in Peripheral Blood Smear of a Patient with Urinary Tract Infection
Erythrophagocytosis refers to the removal of old and damaged red blood cells by leukocytes and macrophages. Observation of erythrophagocytosis in peripheral blood smear is a rare phenomenon that is mostly observed in paroxysmal cold hemoglobinuria and sporadically in some other pathological conditions. Here, we report a case of erythrophagocytosis by monocyte in peripheral blood of a patient wi...
متن کاملCase report: paroxysmal cold hemoglobinuria presenting during pregnancy
BACKGROUND Paroxysmal cold hemoglobinuria is caused by a biphasic IgG autoantibody that triggers complement-mediated intravascular hemolysis. Paroxysmal cold hemoglobinuria has not previously been reported to occur in association with pregnancy. CASE PRESENTATION We report a case of an 18 year old female who presented in early pregnancy with acute hemolytic anemia and a positive Donath-Landst...
متن کامل[An adult case of idiopathic chronic paroxysmal cold hemoglobinuria].
概要 慢 性経過 を示 した特発 性発作性 寒冷血 色素尿症 の1成 人例を報 告 し,文 献 的考察 を加 え た.症 例 は41才,男 性.1978年 冬期,先 行す る熱性疾 患を伴 わず,寒 冷に曝露 した後暗 褐色尿 に気 付 き,以 後毎年同 様 の症状 を繰 り返 すため, 1984年1月 精査 目的にて 当科 入院.貧 血 な し, 肝脾 腫 な し.入 院時検査 所見 で,ヘ モ グロ ビン尿(+), Ehrlich指 試験(+), Rosenbach試 験 (+), Donath-Landsteiner試 験(+),抗 体価4倍 で あ り発 作性寒冷 血色素 尿症 と診 断 した.血 清梅 毒反応(-), TPHA(-)で,血 清抗体価 は マイ コプラス マ,ム ンプス,麻 疹,単 純ヘ ル ペス, EBウ イル スいずれ も陰性 ない し低値 を示 した.経...
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ژورنال
عنوان ژورنال: Annals of Hematology & Oncology
سال: 2017
ISSN: 2375-7965
DOI: 10.26420/annhematoloncol.2017.1151